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Hypercholesterolaemia

Maitake

Reishi

Maitake

1. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Fukushima M, Ohashi T, Fujiwara Y, Sonoyama K, Nakano M. Exp Biol Med (Maywood). 2001;226(8):758–765. 

2. Maitake extracts and their therapeutic potential – A Review. Mayell M. Alt Med Rev. 2001;6(1):48–60. 

3. Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms. Lo YC, Lin SY, Ulziijargal E, Chen SY, Chien RC, Tzou YJ, Mau JL. Int J Med Mushrooms. 2012;14(4):357–363. 

4. Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms. Lin SY, Chen YK, Yu HT, Barseghyan GS, Asatiani MD, Wasser SP, Mau JL. Int J Med Mushrooms. 2013;15(3):315–323.

Reishi

1. Shiitake (Lentinus edodes) Wasser SP. Encyclopedia of Dietary Supplements. 2005. pp. 653–664.

2. Quantitative analysis of eritadenine in ‘Shii-take’ mushroom and other edible fungi. Saito M, Yamashita T, Kaneda T. Eiyo to Shokuryo (J Jap Soc Food Nutr). 1975;28(9):503–505.

3. Quantification of the bioactive compound eritadenine in selected strains of shiitake mushroom (Lentinus edodes). Enman J, Rova U, Berglund KA. J Agric Food Chem. 2007;55(4):1177–1180.

4. Production of the bioactive compound eritadenine by submerged cultivation of shiitake (Lentinus edodes) mycelia. Enman J, Hodge D, Berglund K.A, Rova U. J Agric Food Chem. 2008;56(8):2609–2612.
Hypertension

Reishi

Maitake

Reishi

1. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). Kabir Y, Kimura S, Tamura T. J Nutr Sci Vitaminol. 1988;34(4):433–438. 

2. Effect of Ganoderma lucidum on the quality and functionality of Korean traditional rice wine, yakju. Kim JH, Lee DH, Lee SH, Choi SY, Lee JS. J Biosci Bioeng. 2004;97(1):24–28. 

3. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Lee SY, Rhee HM. Chem Pharm Bull. 1990;38(5):1359–1364.

Maitake

1. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Mol Cell Biochem. 2002;237(1-2):129–136. 

2. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). Kabir Y, Kimura S. J Nutr Sci Vitaminol. 1989;35(1):91–94. 3. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. Kabir Y, Yamaguchi M, Kimura S. J Nutr Sci Vitaminol. 1987;33(5):341–346.
Infertility

Cordyceps

Maitake

Cordyceps

1. Cordyceps sinensis mycelium activates PKA and PKC signal pathways to stimulate steroidogenesis in MA-10 mouse Leydig tumour cells. Chen YC, Huang YL, Huang BM. Int J Biochem Cell Biol. 2005;37(1):214–223. 

2. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Huang BM, Hsiao KY, Chuang PC, Wu MH, Pan HA, Tsai SJ. Biol Reprod. 2004;70(5):1358–1364. 

3. In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse. Huang YL, Leu SF, Liu BC, Sheu CC, Huang BM. Life Sci. 2004;75(9):1051–1062. 

4. Improvement of sperm production in subfertile boars by Cordyceps militaris supplement. Lin WH, Tsai MT, Chen YS, Hou RC, Hung HF, Li CH, Wang HK, Lai MN, Jeng KC. Am J Chin Med. 2007;35(4):631–641. 

5. Immune-Related Female Infertility. Wing T. TCM Kongress Rothenburg, 2012.

Maitake

1. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with firstline clomiphene citrate. Chen JT, Tominaga K, Sato Y, Anzai H, Matsuoka R. J Altern Complement Med. 2010;16(12):1295–1299.
Inflammatory Bowel Disease

Maitake

Reishi

Chaga

Shiitake

Maitake

1. Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling. Lee JS, Park SY, Thapa D, Choi MK, Chung IM, Park YJ, Yong CS, Choi HG, Kim JA. Exp Mol Med. 2010;42(2):143–154.
1. The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid. Hanaoka R, Ueno Y, Tanaka S, Nagai K, Onitake T, Yoshioka K, Chayama K. Scand J Immunol. 2011;74(5):454–462. 

2. Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice. Sliva D, Loganathan J, Jiang J, Jedinak A, Lamb JG, Terry C, Baldridge LA, Adamec J, Sandusky GE, Dudhgaonkar S. PLoS One. 2012;7(10):e47873.
1. Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice. Mishra SK, Kang JH, Kim DK, Oh SH, Kim MK. J Ethnopharmacol. 2012;143(2):524–532. 

2. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease. Najafzadeh M, Reynolds .D, Baumgartner A, Jerwood D, Anderson D. Biofactors. 2007;31(3-4):191–200.
1. Intestinal anti-inflammatory activity of lentinan: influence on IL-8 and TNFR1 expression in intestinal epithelial cells. Nishitani Y, Zhang L, Yoshida M, Azuma T, Kanazawa K, Hashimoto T, Mizuno M. PLoS One. 2013;8(4):e62441.
Influenza

Cordyceps

Maitake

Shiitake

Cordyceps

1. In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans. Ohta Y, Lee JB, Hayashi K, Fujita A, Park DK, Hayashi T. J Agric Food Chem. 2007;55(25):10194–10199.

Maitake

1. Inhibitory effect of TNF-α produced by macrophages stimulated with Grifola frondosa extract (ME) on the growth of influenza A/Aichi/2/68 virus in MDCK cells. Obi N, Hayashi K, Miyahara T, Shimada Y, Terasawa K, Watanabe M, Takeyama M, Obi R, Ochiai H. Am J Chin Med. 2008;36(6):1171–1183.

Shiitake

1. Antiviral and interferon-inducing activities of a new peptidomannan, KS-2, extracted from culture mycelia of Lentinus edodes. Suzuki F, Suzuki C, Shimomura E, Maeda H, Fujii T, Ishida N. J Antibiot. 1979;32(12):1336–1345.
Insomnia

Reishi

Reishi

1. Sleep-promoting effects of Ganoderma extracts in rats: comparison between long-term and acute administrations. Honda K, Komoda Y, Inoué S. Tokyo Ika Shika Daigaku Iyo Kizai Kenkyusho Hokoku. 
1988;22:77–82. 

2. The hypnotic and sedative actions of the spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) in mice. Yu L, Wei H. Int J Med Mushrooms. 2000;2(4):323–328. 

3. Ganoderma lucidum: a potent pharmacological macrofungus. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Curr Pharm Biotechnol. 2009;10(8):717–742

4. Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanis. Chu QP, Wang LE, Cui XY, Fu HZ, Lin ZB, Lin SQ, Zhang YH. Pharmacol Biochem Behav. 2007;86(4):693–698. 

5. Cui XY, Cui SY,Zhang J, Wang ZJ, Yu B, Sheng ZF, Zhang XQ, Zhang YH. Extract Ganoderma lucidum prolongs sleep in rats. J Ethnopharmacol. 2012 Feb 15;139(3):796-800.doi:10.1016/j.jep.2011.12.020
Inflammation

Lion's Mane

Lion's Mane

1. Mori K, Ouchi K, Hirasawa N. The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. Int J Med Mushrooms. 2015;17 (7): 609-18.
Kidney Health

Cordyceps

Lion's Mane

Maitake

Cordyceps

Sun, T.L., W.L. Dong, G.H. Jiang, J.B. Yang, J.H. Liu, L.J. Zhao, P.L. Ma. 2019. Cordyceps militaris improves chronic kidney disease by affecting TLR/NF-B redox signaling pathway. Oxidative Medicine and Cellular Longevity 7850863.

Lion's Mane

1. Qin M, Geng Y, Lu Z, Xu H, Shi JS, Xu X, Xu ZH. Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with ulcerative colitis. Int J Med Mushrooms. 2016;18(3):227-34.doi:10.1615/IntJMedMushrooms.v18.i3.50.

2. Wong JY, Abdulla MA, Ramen J, et al. Gastroprotective Effects of Lion’s mane Mushroom Hericium erinaceus (Bull.:FR.)Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evid Based Complement Alternat Med. 2013;2013:492976, doi: 10.1155.2013/492976

Maitake

1. Lee JS, park Sy, Thapa D, Choi MK, Chung IM, Park YJ, Yong CS, Choi HG, Kim JA. Grifola frondose water extract alleviates intestinal inflammation by supressing TNF-alpha production and its signaling. Exp Mol Med. 2010 Feb 28:42(2):143-54. Doi: 10.3858/emm.2010.42.016.
Liver Damage

Cordyceps

Reishi

Shiitake

Tremella (Snow Fungus)

Cordyceps

1. Cordyceps sinensis supplementation in alcohol-induced liver steatosis. Santos C. Mycology News. 2004;1(9):[2–6]. 2. Inhibitive effect of Cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. Liu YK, Shen W. World J Gastroenterol. 2003;9(3):529–533.

Reishi

1. Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum. Kim DH, Shim SB, Kim NJ, Jang IS. Biol Pharm Bull. 1999;22(2):162–164. 

2. Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice. Shieh YH, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC. Am J Chin Med. 2001;29(3-4):501–507. 

3. Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB. World J Gastroenterol. 2002;8(4):728–733. 

4. Post-treatment of Ganoderma lucidum reduced liver fibrosis induced by thioacetamide in mice. Wu YW, Fang HL, Lin WC. Phytother Res. 2010;24(4):494–499. 

5. Wang, G.-J., Huang, Y.-j., Chen, D.-H and Lin, Y.-L. (2019), ganoderma lucidium extract attenuates the proliferaqtion of hepatic stellate cells by blocking the PDGF receptor. Phytother. Res., 23:833-839. Doi:10.1002/ptr.2687

Shiitake

1. Protection against D-galactosamine-induced acute liver injury by oral administration of extracts from Lentinus edodes mycelia. Watanabe A, Kobayashi M, Hayashi S, Kodama D, Isoda K, Kondoh M, Kawase M, Tamesada M, Yagi K. Biol Pharm Bull. 2006;29(8):1651–1654.

Tremella

1. Guo, Z., X.H. Tan. 2005. The curative effect of Tramella polysaccharide enteric-coated capsules in preventing and treating acute liver injury after blood tumor chemotherapy. Infect Dis Inf 18:71265.
Meniere’s Syndrome

Turkey Tail

Turkey Tail

1. Nutritional mushroom treatment in Meniere’s Disease with Coriolus versicolor: a rationale for therapeutic intervention in neuroinflammation and antineurodegeneration. Scuto M, Di Mauro P, Ontario ML, Amato C, Modafferi S, Ciavardelli D, Trovato Salinaro A, Maiolino L, Calabrese V. Int J Mol Sci, 2019;21(1):284.
Multiple Sclerosis

Lion's Mane

Lion's Mane

1. The influence of Hericium erinaceus extract on myelination process in vitro. Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. Fiziol Zh. 2003;49(1):38–45.