Can Functional Mushrooms Help Manage Alzheimer’s Disease?

Ageing is mostly associated with weaker physical strength and stamina, and being more prone to severe symptoms of otherwise everyday illnesses. 

However, ageing also affects our brain. As we get older, we become more prone to shorter memory retention, poorer focus, and often struggle to learn new concepts.

In some cases, these mental deficiencies are a result of age-related brain disorders like Alzheimer’s Disease.

Alzheimer’s Disease is described as a neurological disorder that impacts on a person’s ability to remember, think, and eventually their ability to be an independent adult. While most patients show signs of Alzheimer’s when they enter their late 60s, early-onset Alzheimer’s can start as early as 40 years. 

Symptoms of Alzheimer’s Disease

According to the NHK, Alzheimer’s disease symptoms progress slowly over several years, and the rate of progress with each symptom varies for each person.

Alzheimer’s symptoms can be classified into three major groups:

Early

• Often attributed to memory loss or lapses
• You forget conversations and events easily
• You misplace items
• Have trouble remembering places and objects
• Difficulty in finding the right words
• Mood swings 

Middle Stage

• More severe memory loss
• Struggling to remember the names of people they know
• Confusion and disorientation
• Impulsive behaviour
• Delusions
• Speech or language difficulties
• Sleep disturbance
• Frequent mood swings
• Some experience hallucinations

Late 

• Previous symptoms become severe
• Causes distress not just to the patient, but to their family and carers too
• Some patients become violent or suspicious of people around them
• Problems with movement, eating, and maintaining weight
• Urinary or bowel incontinence

In the late stages, Alzheimer’s patients may need full-time care and assistance with moving, eating, and personal hygiene.

Sadly there is no cure for Alzheimer’s disease yet, but there are many ways to reduce symptoms through medication. The goal of Alzheimer’s treatment is to provide patients with comfort, dignity, independence, and to make it easier for caregivers to assist them.

Some of the common medications used for Alzheimer’s are rivastigmine, galantamine, and donepezil. These drugs work as cholinesterase inhibitors that reduce the breakdown of acetylcholine, a brain chemical responsible for memory and cognition. 

• We typically have lower concentrations of acetylcholine as we age, but Alzheimer’s breaks them down faster.

There is another drug that specifically targets the underlying cause of Alzheimer’s called aducanumab. 

Aducanumab is a human antibody that reduces amyloid plaques or brain lesions associated with Alzheimer’s disease. If treatment is successful, this would slow down the progress of the neurological disorder. This drug is still new and only intended for early and mid-stages.

Late-stage patients are also sometimes prescribed antipsychotics or other drugs to relieve distress or calm down aggression.

Conventional Alzheimer’s Treatments

As with conventional treatment for most diseases, prescription drugs can pose a high risk for side effects. Depending on what you’re prescribed, these are some of the symptoms to watch out for:

• Sleep disruption
• Bleeding
• Slow heart rate, which can cause fainting
• Confusion
• Agitation
• Constipation

Patients with conditions that pre-dispose them to having those side effects are barred from taking Alzheimer’s medications.

Other than side effects, prescription drugs also don’t always work or don’t have the expected impact on Alzheimer’s disease symptoms. 

Due to the uncertainty and severity of side effects associated with traditional Alzheimer’s treatment, experts are turning their heads to alternative approaches that meet safety and efficacy. One of them is through the healing powers of mushrooms, especially reishi and lion’s mane.

Lion’s Mane mushroom

Possesses compounds that stimulate brain-cell growth: Hericenones and erinacines. These compounds were found to specifically fight against Alzheimer’s disease as well as other neurological conditions that cause memory loss in animal studies. [1] 

Lion's Mane’s hericenones and erinacine content can also support neuron outgrowth. Increasing neuron production potentially slows or reverses age-related cell degeneration in conditions like Alzheimer's. [6]

The mushroom is also known to be anti-inflammatory, and Alzheimer’s can also be categorized as an inflammatory condition. 

Studies suggest Lion’s Mane’s possesses natural anti-inflammatory properties that fight markers of Alzheimer’s like amyloid plaques. Amyloid plaques accumulate in the brain during Alzheimer’s disease. [5]

The mushroom’s extracts have also been cited to reduce symptoms of memory loss and prevent neuronal damage caused by amyloid plaques in animal studies. [5]

Reishi mushroom

Reishi is a source of powerful antioxidants and has been cited to reduce cell ageing. 

In fact, reishi is credited to have the most anti-ageing effects of all medicinal mushrooms. Reishi extracts are also known to protect cellular DNA from oxidant damage, which can lead to early signs of aging and cancer. [2]

What about Alzheimer’s? Because Alzheimer’s is largely a cell-aging disease, experts suggest taking reishi can slow down its progress primarily by promoting neurogenesis. 

Neurogenesis is a process necessary for maintaining brain functions like mood and cognition. Moreover, enhancing neurogenesis can help counteract neurodegeneration, which leads to Alzheimer’s disease. [7]

The contents found in reishi can also limit the damage done by AGEs or advanced glycation end products. AGEs are proteins whose malfunction promotes aging and inflammation and contribute to Alzheimer’s risk. [8]

You should go for a Lion’s Mane supplement that uses both mycelium and fruiting body. This is important as Hericenones are found in the fruiting body, whereas Erinaceus is found in the mushroom's mycelium. These two compounds are responsible for the fungus’ cognitive health benefits. [1]

The Reishi supplement has to be a triterpene-rich extract. Make sure the lab report shows that the mushroom has been tested for the triterpene content. The Beta D Glucan content is also important.

• One study noted how high cholesterol levels are a marker for Alzheimer’s, so taking reishi with high Beta D Glucans might help reduce risks. [3]

For a comprehensive checklist on choosing a quality mushroom supplement, see this article here.

Dosage Recommendation

Adding functional mushrooms to your diet is easier than you might think. Here are some simple ways to incorporate this superfood into your daily routine:

• Baseline Dose: Start with 2 capsules or 1 gram per day for general wellness. This helps you experience the foundational benefits of the mushrooms.
• Enhanced Dose: For more pronounced effects, please get in touch with us. Our team can help you determine the best approach for your needs.
  
  

Choosing the Right Mushroom Supplement

With so many mushroom supplements on the market, it's important to choose a high-quality product. Here are some tips to help you make an informed decision:

✅ Look for Pure Ingredients: Ensure the supplement contains pure mushroom extract without fillers or additives.

✅ Check for Certification: Choose products that are certified organic and free from pesticides or harmful chemicals.

✅ Reputable Brands: Opt for supplements from reputable brands that adhere to high manufacturing standards and undergo third-party testing.

Side Effects and Safety

Lion's mane should not be used by Asthmatic individuals. 

If you have a mushroom allergy, you should not use these mushroom extracts. Caution is advised if using mushrooms along with blood thinning medication.

References 

1. Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. doi: 10.1615/intjmedmushr.v15.i6.30. PMID: 24266378.

2. Wang J, Cao B, Zhao H, Feng J. Emerging Roles of Ganoderma Lucidum in Anti-Aging. Aging Dis. 2017 Dec 1;8(6):691-707. doi: 10.14336/AD.2017.0410. PMID: 29344411; PMCID: PMC5758346.

3. Rahman MA, Hossain S, Abdullah N, Aminudin N. Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Ameliorates Spatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease. Int J Med Mushrooms. 2020;22(1):93-103. doi: 10.1615/IntJMedMushrooms.2020033383. PMID: 32464001.

4. McCleary BV, Draga A. Measurement of β-Glucan in Mushrooms and Mycelial Products. J AOAC Int. 2016 Mar-Apr;99(2):364-73. doi: 10.5740/jaoacint.15-0289. Epub 2016 Mar 8. PMID: 26957216.

5. Tsai-Teng T, Chin-Chu C, Li-Ya L, Wan-Ping C, Chung-Kuang L, Chien-Chang S, Chi-Ying HF, Chien-Chih C, Shiao YJ. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016 Jun 27;23(1):49. doi: 10.1186/s12929-016-0266-z. PMID: 27350344; PMCID: PMC4924315.

6. Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. doi: 10.1615/intjmedmushr.v15.i6.30. PMID: 24266378.

7. Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G. Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease. Stem Cell Reports. 2017 Jan 10;8(1):84-94. doi: 10.1016/j.stemcr.2016.12.007. PMID: 28076758; PMCID: PMC5233449.

8. Chen Y, Qiao J, Luo J, Wu F, Meng G, Chen H, Zheng H, Xu J. [Effects of Ganoderma lucidum polysaccharides on advanced glycation end products and receptor of aorta pectoralis in T2DM rats]. Zhongguo Zhong Yao Za Zhi. 2011 Mar;36(5):624-7. Chinese. PMID: 21657085.